The bioavailability of hydrolyzed
collagen in mice was demonstrated in a 1999 study; orally administered C
hydrolyzed collagen was digested and more than 90% absorbed within 6 hours,
with measurable accumulation in cartilage and skin. A 2005
study in humans found hydrolyzed collagen absorbed as
small peptides in the blood.
Effects on skin
Ingestion of hydrolyzed collagen may
affect the skin by increasing the density of collagen fibrils
and fibroblasts, thereby stimulating collagen production. It has been
suggested, based on mouse and in vitro studies, that hydrolyzed collagen
peptides have chemotactic properties on fibroblasts or an influence
on growth of fibroblasts.
Joint and bone effects
Some clinical studies report that the
oral ingestion of hydrolyzed collagen decreases joint pain, those with the most
severe symptoms showing the most benefit. Beneficial action is likely due
to hydrolyzed collagen accumulation in the cartilage and stimulated
production of collagen by the chondrocytes, the cells
of cartilage. Several studies have shown that a daily intake of
hydrolyzed collagen increases bone mass density. It seems that hydrolyzed
collagen peptides stimulated differentiation and osteoblast
activity- the cells that build bone- – over that
of osteoclasts (cells that destroy bone).